Integrando farmacologia de rede e docagem molecular para avaliar o potencial terapêutico da tangeritina contra o meduloblastoma
DOI:
https://doi.org/10.24933/rep.v8i1.463Keywords:
Flavones, Tangeretin, Medulloblastoma, Network Pharmacology, BioinformaticsAbstract
Tangeretin is an antioxidant flavone with anticancer effects capable of inhibiting the development and progression of cancer cells. Due to these properties and the statistical relevance of cancer in the central nervous system, with 11,490 cases per 100,000 inhabitants between 2023 and 2025, the study of natural compounds applied to brain tumors emerges as a promising approach. Due to the challenges in early diagnosis and treatment, with metastasis being the leading cause of mortality, medulloblastoma, primarily pediatric, requires further research focused on developing new therapies that could reduce metastasis cases and the side effects of conventional therapies. Protein-protein interaction (PPI) network analyses revealed therapeutic targets such as EGFR, AKT1, SRC, GSK3B, PARP1, MMP9, PTGS2, MCL1, ABCB1. After clustering, molecular docking of the SRC gene confirmed that tangeretin presented a satisfactory binding energy of -6.33 kcal/mol and an RMSD of 0, indicating high affinity and therapeutic potential. Functional enrichment of the signaling pathways indicated the relevance of the EGFR-TKI, PI3K-Akt, Chemical Carcinogenesis - ROS, Estrogen Signaling, Ras Signaling, MAPK Signaling, and FoxO Signaling pathways. The modulation of these pathways by tangeretin suggests a positive therapeutic approach in reducing carcinogenesis progression and improving the response to chemotherapy.
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